Isotopically Labeled Compounds
Medchemexpress LLC Amlodipine-d4 maleate | 2714486-25-4 | 98.2% | 1 MG
Amlodipine-d4 maleate | 2714486-25-4 | 98.2% | 1 MG
Medchemexpress LLC Acetamide, N-[4-(ethoxy-d5)phenyl]- | 69323-74-6 | 99.5% | 50 MG
Phenacetin-d5 is a deuterium-labeled form of Phenacetin, a non-opioid analgesic and antipyretic agent. It functions as a selective COX-3 inhibitor and is utilized as a probe for cytochrome P450 enzymes CYP1A2 in human liver microsomes and in rats.
- Deuterium-labeled Phenacetin
- Non-opioid analgesic and antipyretic
- Selective COX-3 inhibitor
- Used as a probe for cytochrome P450 enzymes CYP1A2
Medchemexpress LLC Mebeverine acid-d5, hydrochloride | 475203-77-1 | 99.0% | 1 MG
Mebeverine acid-d5 hydrochloride is a deuterium labeled form of Mebeverine acid hydrochloride, a secondary metabolite of the intestinal antispasmodic agent Mebeverine. It is formed by the body's hydrolysis of Mebeverine, acting as a key circulating metabolite and an important marker for oral Mebeverine. This compound is intended for research use only, leveraging stable heavy isotopes for quantitation in drug development.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Bupivacaine-d9 | 474668-57-0 | MFCD11977968 | 99.0% | 1 MG
Bupivacaine-d9 is a deuterium-labeled Bupivacaine, functioning as an NMDA receptor inhibitor. It effectively blocks sodium, L-calcium, and potassium channels and can be utilized in chronic pain research.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Ropivacaine-d7 | 684647-62-9 | 99.7% | 5 MG
Ropivacaine-d7 is deuterium labeled Ropivacaine. Ropivacaine is a potent sodium channel blocker, which blocks impulse conduction by reversibly inhibiting sodium ion influx in nerve fibers. It is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. Ropivacaine is used for the research of neuropathic pain management. It can be used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium labeled Ropivacaine
- Potent sodium channel blocker
- Inhibits impulse conduction by reversibly inhibiting sodium ion influx
- Inhibitor of K2P (two-pore domain potassium channel) TREK-1
- Used for research in neuropathic pain management
- Can be used as a tracer or internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Related to isotope-labeled compounds
- Useful for therapeutic drug monitoring
Medchemexpress LLC Tilmicosin-d3 | 2714486-61-8 | 5 MG
Tilmicosin-d3 is the deuterium labeled Tilmicosin. Tilmicosin (LY-177370) is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. It primarily acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis.
- Effective in treating respiratory diseases in livestock such as cattle, sheep, and pigs.
- Possesses immunomodulatory and anti-inflammatory effects.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC O-Toluic acid-d7 | 207742-73-2 | MFCD00216766 | 99.5% | 143.19 | 100 MG
O-Toluic acid-d7 is the deuterium labeled form of o-Toluic acid (2-Methylbenzoic acid), which is a benzoic acid with a methyl group at position 2. This compound functions as a xenobiotic metabolite and is intended for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC 7-keto-Deoxycholic acid | 911-40-0 | 99.7% | 406.56 | 50 MG
7-keto-Deoxycholic acid is a metabolite of bile acids found in *Clostridium absonum*. It can also be converted from *Lactobacillus* and *Bifidobacterium* under specific conditions. It shows an increasing bioconversion rate with the addition of an equimolar concentration of deoxycholic acid and is induced by deoxycholic acid and then metabolized. *E. lentum*-like c-25 converts 81.7% of 2 mM cholic acid to deoxycholic acid and 3.7% to 7-keto-Deoxycholic acid under anaerobic incubation. *E. lentum*-like c-25 also converts 91.5% of 150 mg/mL cholic acid to deoxycholic acid and 1.1% to 7-keto-Deoxycholic acid under anaerobic incubation.
- Metabolite of bile acids
- Found in Clostridium absonum
- Converted from Lactobacillus and Bifidobacterium
- Solid appearance
- White to off-white color
- Classified as ketones, aldehydes, and acids
- Endogenous metabolite
- Soluble in DMSO at 100 mg/mL
Cayman Chemical DesIpramIn-d4hydrochlorIde 5mg
An internal standard for the quantification of desipramine by GC- or LC-MS
Medchemexpress LLC Theophylline-d6 | 117490-39-8 | 99.3% | 1 MG
Theophylline-d6 is the deuterium labeled Theophylline, a nonselective phosphodiesterase (PDE) inhibitor, adenosine receptor blocker, and histone deacetylase (HDAC) activator. Stable heavy isotopes are incorporated into drug molecules as tracers for quantitation during the drug development process, with deuteration potentially affecting pharmacokinetic and metabolic profiles.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable isotope-labeled compound
- Used in internal standards for clinical mass spectrometry
- Deuterium (2H, D) stable isotope-labeled inhibitor
- Used in therapeutic drug monitoring (TDM)
Medchemexpress LLC Pendimethalin-d5 | 1219803-39-0 | 99.9% | 1 MG
Pendimethalin-d5 is the deuterium labeled Pendimethalin. Pendimethalin is an herbicide that controls annual grasses and certain broadleaf weeds. It inhibits cell division and cell elongation.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
Cayman Chemical GrnIsetron-d3 1mg
An internal standard for the quantification of granisetron by GC- or LC-MS
Cayman Chemical MyrIstIc AcId-13C 250mg
An internal standard for the quantification of myristic acid by GC- or LC-MS
Medchemexpress LLC 2-naphthol-d7 | 78832-54-9 | MFCD01074243 | 95.0% | 151.22 g/mol | C10HD7O | 100mg
2-Naphthol-d7 is the deuterium labeled 2-Naphthol[1] 2-Naphthol is a metabolite of naphthalene catalyzed by cytochrome P450 (CYP) isozymes (CYP 1A1 CYP 1A2 CYP 2A1 CYP 2E1 and CYP 2F2)[2]
Sigma Aldrich Fine Chemicals Biosciences ISOGROR 13C Powder Growth1G
ISOGRO(R) media is required for overcoming the growth limitations of minimal media. ISOGRO products are lysates of algae grown with stable isotopes (13C 15N and/or D). ISOGRO(R)-13C powder -growth medium gives uniform labeling for protein expression NMR (nuclear magnetic resonance) studies.A typical algal lysate (ISOGRO medium) contains 30% salts 3% water 2% glucose and 65% amino acids/peptides.
